Can my Lenovo Y510p Laptop run fallout 4? If so, what should I set the settings on?

According to technical specs, "Lenovo Y510p" has got built-in dedicated Dual NVIDIA GeForce GT750M graphics card
http://www.amazon.com/...00F0RC4VQ/

It will play Fallout 4 at medium settings. Open graphics card specs at http://www.notebookcheck.net/...280.0.html and scroll down to "Game Benchmarks"

Go to http://www.geforce.com/...om/drivers and download & install latest available drivers to see significant improvement in graphics & sound quality when playing video games

It 'could' but i can't attest to how many fps you will get even at lower graphics settings.